Abstract: With their diverse range of biological actions, 1,3,4-trisubstituted pyrazoles have become significant compounds in medicinal chemistry, especially in the study of cancer. Since 1,3,4- trisubstituted pyrazole derivative have been demonstrated to have analgesic, anti-inflammatory, and anticancer actions, this study focuses on their pharmacological characteristics. Compounds that block cyclin-dependent kinases (CDKs) are notable examples because they cause cell cycle arrest and apoptosis in multiple cancer cell lines. Disrupting angiogenesis and tumor progression, these compounds have also shown encouraging inhibitory efficacy against vascular endothelial growth factor receptors (VEGFRs). According to recent research, several 1,3,4-trisubstituted pyrazoles have strong cytotoxic effects against a variety of cancer types, including solid tumors and leukemia, with IC₅₀ value in the lower micromolar ranges. Furthermore, by specifically targeting important enzymes involved in the growth of cancer, some derivatives have been demonstrated to increase the effectiveness of already available chemotherapeutics. The promise of 1,3,4-trisubstituted pyrazoles as lead compounds for the creation of innovative anticancer treatments is highlighted in this review, which also emphasizes the need for more research to completely clarify their therapeutic potential due to their complex methods of action.

Keywords: 1,3,4-trisubstituted pyrazole, anticancer, VEGFR, CDK.

Title: Mechanisms and anticancer therapeutic potential of 1,3,4-trisubstituted pyrazole derivatives (mini review)

Author: Omar Alshazly, Mohamed Abdel-Aziz, Mamdouh F. A. Mohamed, Gamal El-Din A. Abuo-Rahma

International Journal of Novel Research in Physics Chemistry & Mathematics

ISSN 2394-9651

Vol. 12, Issue 1, January 2025 - April 2025

Page No: 25-34

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 12-February -2025

Abstract: A proposal based on the concepts of the human genetics in the light of the Mendel's laws are including the sexual characteristics of the male and female. The female characteristics is (X) to male masculinity(Y-Y) to form(Y-X-Y) in sperm and the male charactistics is(Y) to female feminility (X-X) to form(X-Y-X) in egg. After fertilization process (sperm fuses with the egg) to form embryo(fetus) setting in the mother uterus, the growth will begins.

Keywords: Mendel's laws, Sex hormone, zygote division.

Title: A proposal based on concepts of human genetics and in the light of Mendel's laws was setting

Author: Dr. Ziadan Jassim Khalaf

International Journal of Novel Research in Physics Chemistry & Mathematics

ISSN 2394-9651

Vol. 12, Issue 1, January 2025 - April 2025

Page No: 22-24

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 12-February -2025

Abstract: In this article, we show how to construct an infinite family of generalized Pythagorean triples.  Then, we consider how Fermat's Last Theorem relates to this construction.

Keywords: Pythagorean triple, primitive Pythagorean triple, convergent infinite geometric series, Fermat's Last Theorem.

Title: CONSTRUCTING INFINITE FAMILIES OF GENERALIZED PYTHAGOREAN TRIPLES

Author: Ronald Skurnick

International Journal of Novel Research in Physics Chemistry & Mathematics

ISSN 2394-9651

Vol. 12, Issue 1, January 2025 - April 2025

Page No: 18-21

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 11-February -2025

Abstract: The X-ray tube remains one of the few vacuum tubes that has not been replaced by solid-state technology, alongside magnetron tubes and other high-voltage vacuum tubes used in radar systems. While many vacuum tubes are readily available online at reasonable prices, X-ray tubes are not produced in the same quantities and are often difficult to obtain, making them quite expensive. This situation is particularly problematic given that X-rays are valuable not only for large-scale industrial and medical imaging but also for small-scale research in fields like physics, chemistry, and electronics. A more affordable and compact X-ray tube would greatly benefit small-scale research efforts. This paper explores the development of such a tube.

Keywords: X-ray tube, solid-state technology, radar systems.

Title: Development of X-ray tube for low power X-ray applications

Author: Maximilian Aaron Jelačić

International Journal of Novel Research in Physics Chemistry & Mathematics

ISSN 2394-9651

Vol. 12, Issue 1, January 2025 - April 2025

Page No: 13-17

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 14-January -2025

Abstract: This paper proposes a new distribution called New Generalized XLindley distribution (NGXLD), this distribution is generated as an extension of Xlindley distribution and hence the name proposed. Statistical properties like the maximum likelihood estimation method and moment were used in estimating the parameters of the proposed distribution. The Kolmogorov Smirnov goodness of fit was tested with four retrieved different datasets, compared with some selected existing model and shows more efficient than the considered models.

Keywords:  Coronavirus, Harmonic Mean, Kolmogorov Smirnov, Maximum Likelihood Estimation, Quasi XLindley Distribution, Xlindley distribution, Weighted Distribution.

Title: NEW GENERALIZED XLINDLEY DISTRIBUTION: ITS PROPERTIES AND APPLICATION TO LIFETIME DATA

Author: TOYIN ELIJAH FANIYI, THOMPSON ELO IDIKE

International Journal of Novel Research in Physics Chemistry & Mathematics

ISSN 2394-9651

Vol. 12, Issue 1, January 2025 - April 2025

Page No: 1-12

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 01- January -2025