Abstract: Alzheimer’s disease (AD) is a devastating mental illness with an irreversible progressive brain disorder that slowly destroys memory skills and learning abilities. No treatments stop or reverse the progression of Alzheimer's disease, though some may temporarily improve symptoms. Hence, the limitations of these treatment methods necessitate the search for an alternative among the herbs available to man. Lasianthera africana locally known as "Editan" in Ibibio and Annang tribes of Southern Nigeria, has pharmacological benefits which includes; possession of analgesic, antipyretic, antimalarial, anti-ulcerogenic, antimicrobial, antidiabetic, anti-inflammatory, antioxidant, hepatoprotective and cardioprotective. Computational methods were used to study the binding interaction of 44 compounds derived from lasianthera africana against four target receptors (butyrylcholinesterase, beta secretase enzyme 1, protein tyrosine phosphate 1B and glycogen synthase kinase-3 beta) out of which, top four compounds (quercetin, epicatechin, oleandrin and quercetin 3-methyl ether) were selected based on their binding affinities. These four compounds in comparison with domepezil (reference drug) were subjected to drug-likeness screening to examine their physiochemical properties and admet analysis to examine their pharmacokinetical properties. These four ligands showed the best pharmacokinetic and physicochemical properties, including good absorption, distribution, metabolism, and excretion (ADMET) and admetSAR toxicity tests. It is demonstrated that quercetin, oleandrin, epicatechin and quercetin-3-methyl ether have promising therapeutic effect on Alzheirmer’s disease and Oleandrin exhibited a higher binding affinity and also a lower level of toxicity than the reference drug domepezil.

Keywords: Alzheimer’s, phytocompounds, Lasianthera-africana, Admet, Domepezil.

Title: Insilico Studies and Pharmacokinetic Properties of Anti-Alzheirmer’s Disease Activities of Phytocompounds Derived from Lasianthera Africana

Author: Dearsly, Emmanuel Markus; Eze, Kingsley Chijioke; Chukwu, Constance Adaeze; Ofem, Lilian William

International Journal of Novel Research in Life Sciences                                                    

ISSN 2394-966X

Vol. 11, Issue 5, September 2024 - October 2024

Page No: 58-73

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 24-October-2024

Abstract: This paper explores the potential of deep learning in dental radiology, particularly in disease detection, image segmentation, and treatment planning. CNNs have been successful in diagnosing caries, periodontal disease, and oral cancer from radiographs and CBCT scans, while also automating dental structure segmentation. Key challenges include limited annotated data, model transparency, and generalizability. Ethical concerns like data privacy and bias are addressed, along with future developments such as advanced imaging integration, federated learning, and explainable AI, positioning deep learning to enhance diagnostic accuracy and personalized treatment in dental care.

Keywords: Dental Radiology, Deep Learning, Treatment.

Title: Dental Imaging Analysis with Artificial Intelligence

Author: Shima Minoo, Fariba Ghasemi

International Journal of Novel Research in Life Sciences                                                    

ISSN 2394-966X

Vol. 11, Issue 5, September 2024 - October 2024

Page No: 54-57

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 21-October-2024

Abstract: The use of indigenous or local technological knowledge in teaching and learning can anchor the study of subjects including Biology on the principle of learning from the known to the unknown. Therefore the aim of this study was to ascertain the existing local technological knowledge of the Sissala East Municipality and how to integrate them into teaching and learning of Biology in Senior High Schools in the Municipality. Cross-sectional survey was used to collect data from six Biology teachers and 30 local technological knowledge experts. The study revealed that majority of the teachers (83.3%) were of the opinion that it is difficult integrating local knowledge into teaching and learning of Biology. The challenges among others include poor teacher background knowledge in local technological knowledge (mean of 3.7) and unsupportive government policies (mean of 4.2). Some of the existing local technological knowledge that could be used in teaching and learning Biology are local conservation techniques and sustainable use of natural resources (mean of 4.15) as well as totems and taboos (mean of 4.99). Strategies that could be used to integrate local technological knowledge in the teaching and learning of Biology include invitation of  local craftsmen to schools during Biology lessons to assist teachers (mean of 3.8) and incorporating indigenous technologies into national curriculum (mean of 4.2). It was recommended that educational authorities in senior high schools in Sissala East Municipality should encourage Biology teachers to utilize local technological knowledge in teaching and learning of Biology.

Keywords: Local, technology, knowledge system, teaching, Biology, conventional concepts, strategies, Sissala East Municipality.

Title: LOCAL TECHNOLOGICAL KNOWLEDGE FOR TEACHING AND LEARNING BIOLOGY IN SENIOR HIGH SCHOOLS IN THE SISSALA EAST MUNICIPALITY, GHANA

Author: Abraham BARSON, Wisdom Harrison Kofi HORDZI

International Journal of Novel Research in Life Sciences                                                    

ISSN 2394-966X

Vol. 11, Issue 5, September 2024 - October 2024

Page No: 39-53

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 09-October-2024

Abstract: Mango (Mangifera indica L.) is a crucial fruit crop with substantial economic and nutritional importance worldwide. The pollination of mango flowers, primarily facilitated by a diverse group of insects, is essential for fruit set and yield. However, habitat destruction poses a significant threat to these vital pollinators. This review explores the impact of habitat loss on the diversity and abundance of mango flower visitors, examining the underlying causes and consequences. Habitat destruction, driven by urbanization, agricultural expansion, deforestation, and climate change, results in the fragmentation and degradation of ecosystems. These changes lead to the loss of floral resources, nesting sites, and shelter for pollinators. Consequently, the population dynamics of key mango flower visitors, including bees, flies, butterflies, and beetles, are adversely affected. Reduced pollinator diversity and abundance can lead to poor pollination services, impacting mango fruit production and quality. The review highlights studies documenting the decline in pollinator populations and the resultant decrease in mango yields. It also discusses the role of specific pollinators in mango pollination and the interdependence between mango trees and their pollinators. Strategies to mitigate these threats, such as habitat restoration, conservation of native vegetation, and the implementation of pollinator-friendly agricultural practices, are also explored. In conclusion, the conservation of mango flower visitors is paramount for sustaining mango production. Addressing habitat destruction and implementing effective conservation measures are critical to preserving pollinator populations and ensuring the continued availability of this vital fruit crop.

Keywords: Biodiversity, Conservation, Decline, Ecosystem, Pollinators, Pollutants.

Title: THREATS TO INSECT MANGO FLOWER VISITORS DUE TO HABITAT DESTRUCTION: A REVIEW

Author: CAROLINE WANJIKU MWIHIA, STEPHEN KIRUTHI MWIHIA

International Journal of Novel Research in Life Sciences                                                    

ISSN 2394-966X

Vol. 11, Issue 5, September 2024 - October 2024

Page No: 26-38

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 18-September-2024

Abstract: Honey is a natural, sugary, sticky and nutritious liquid product produced from the nectars of flowers by honey bees. Its composition depends highly on the flowers utilized by the bee as well as the climatic conditions. This study was intended to evaluate the physicochemical and selected concentration of heavy metals in ten honey samples. The physicochemical properties of the samples (moisture, pH, Ash, Sucrose, Insoluble material, acidity (free, total and lactone), electrical conductivity, reducing sugars and hydroxymethyl furfural) were determined. The concentration of heavy metals (Zn, Cu, Mn, Cd, Cr and Pb) were also determined using on atomic absorption spectrophotometer. The moisture shows value range from 13.90 to 19.04%. The water insoluble material content ranged from 0.014 to 0.710g/100g. The reducing sugars were between 66.83 to 88.48%, mean percentages of apparent sucrose ere 8.96%, Honey samples showed an appropriate HMF (hydroxymethy furfural content ranging from 6.77 to 36.42 mg/kg. The ash content ranged from 0.099 to 0.600%. Conductivity values ranged from 15.0 to 536µ/cm. All honey samples were acidic, having a pH in the range 3.75 to 4.78. The average values for free acidity were between 10.0 to 26mg/kg. Lactonic acidity ranged were 2.5 to 5.3meg/kg. The total acidity ranged from 12.10 to 30.0 meg/kg. The concentration of heavy metals Zn, Cu, and Mn became the highest values than the other metals and the concentration of Pb and Ni in all samples were below detection limits.

Keywords: Honey bee, Metals, Enugu honey, Physico-chemical properties, FAAS.

Title: QUALITY ASSESSMENT OF SELECTED HONEY BEE SPOT AND BRANDED HONEY PRODUCTS IN ENUGU METROPOLIS

Author: Kolawole Oladimeji Olubusayo, Ekele Dinneya-Onuoha, Vivian Chinekwu Onwujiogu, Okorafor-Nwosu Adaku, Anigbogu, Chinenye Bibiana, Ogburubi Orieoma Ibeuro

International Journal of Novel Research in Life Sciences                                                    

ISSN 2394-966X

Vol. 11, Issue 5, September 2024 - October 2024

Page No: 19-25

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 11-September-2024

Abstract: The proximate, physical and textural properties of gluten-free bread produced from formulated blends of cassava, defatted soybean and malted sorghum were studied. The cassava tuber was processed to get high-quality cassava flow (HQCF). The malted sorghum and defatted soybean were processed using standard methods and sixteen samples were formulated from the blends of cassava defatted soybean and malted sorghum flour in the different ratios. A preliminary investigation was carried out on the raw materials used for the production of the gluten-free bread. Proximate composition of the composite flour blends revealed, that the moisture ranged from 5.25 to 6.79%, protein (6.14 to 9.61%), ash (0.86 to 4.79%), fat (0.68 to 1.12%), fibre (3.10 to 6.82%), carbohydrate (72.38 to 83.84%) and energy content (332.48 to 366.55 kcal); the physical properties of bread and dough showed that the loaf volume, loaf weight, specific loaf, firmness, viscosity and torque were investigated. The values ranged from 200 to 276cm³, 110 to 182g, 1.57 to 2.19 cm³/g, 8.44 to 12 to 0.93 Nm, respectively. Textural properties of the finished product were as followed: Hardness (0.46 to 18.20N), springiness (0.69 to 0.93 mm), cohesiveness (0.83 to 0.85 mm), chewiness (6.41 to 8.65 kg/mm), and resilience (0.35 to 0.78m). The results clearly showed that the blends of cassava, defatted soybean, and malted sorghum can be used as replacement in bread production.

Keywords: Bread, Gluten-free, Malted Sorghum, Textural, Defatted soybean.

Title: PHYSICO-CHEMICAL AND TEXTURAL PROPERTIES OF GLUTEN-FREE BREAD FORMULATED WITH CASSAVA, DEFATTED SOYBEAN AND MALTED SORGHUM FLOUR BLENDS

Author: Ogburubi Orieoma Ibeuro, Ishiwu Charles Ngwuja, Helen Obioma Agu, Kolawole Oladimeji Olubusayo, Ahmed John Enemona, Okorafor-Nwosu Adaku, Chimezie Philip Emeka

International Journal of Novel Research in Life Sciences                                                    

ISSN 2394-966X

Vol. 11, Issue 5, September 2024 - October 2024

Page No: 7-18

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 11-September-2024

Abstract: The genus Kockiozyma was introduced as the ninth and the monotypic genus in the family Lipomycetaceae. On the other hand, a number of anamorphic species were reported in the genus Myxozyma. This paper deals with the phylogenetic relationships between the teleomorphic species, Kockiozyma suomiensis and the anamorphic species. To constitute a taxonomic homogeneous-natured genus, 1) the several species concerned have to be tightly coupled with one another phylogenetically. 2) To make the several species tightly coupled, the branch lengths have to be short or the calculated sequence similarities have to be 98% or more among the species in the 18S rRNA gene sequences. Thus, the following seven Myxozyma species were accommodated to the genus Kockiozyma as Kockiozyma geophila f.a., Kockiozyma sirexii f.a., Kockiozyma neotropica f.a., Kockiozyma vanderwaltii f.a., Kockiozyma mucilagina f.a., Kockiozyma neglecta f.a. and Kockiozyma melibiosi f.a.

Keywords: Kockiozyma suomiensis; Myxozyma geophila; Kockiozyma geophila f.a.; Kockiozyma melibiosi f.a.; Zygozyma oligophaga.

Title: The Generic Circumscription of Kockiozyma (Lipomycetaceae)

Author: Taweesak Malimas, Huong Thi Lan Vu, Somboon Tanasupawat, Yuzo Yamada

International Journal of Novel Research in Life Sciences                                                    

ISSN 2394-966X

Vol. 11, Issue 5, September 2024 - October 2024

Page No: 1-6

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 09-September-2024