Abstract: The highly adaptive cellular response of Mycobacterium tuberculosis to various antibiotics, combined with the high costs of clinical trials, hamper the development of novel antimicrobial agents with improved efficacy and safety. Subsequently, in silico drug screening methods are increasingly used in drug discovery and development and have proven useful for predicting the pharmacokinetics, toxicities, and targets of prospective new antimicrobial agents. In this investigation, we employed a reverse target fishing approach to identify potential hit targets and explore their interactions between M. tuberculosis and a promising new antituberculosis compound. Two of the four identified targets, Cyp130 and 1SFR, were strongly proposed as optimal drug targets for dormant M. tuberculosis, with Cyp130 exhibiting the highest binding affinity. The metabolic pathways associated with the selected target proteins were compared to previously published molecular mechanisms of Cyp130 in M. tuberculosis, confirming disruptions in the metabolism of proteins, cell wall components, and DNA. We also detailed the specific steps within these pathways that are inhibited and elaborated on the role of Cyp130 against dormant M. tuberculosis. This compound has previously shown promising in vitro safety and good oral bioavailability, both of which were supported by this in silico study. The pharmacokinetic properties and toxicity of the compound were predicted and evaluated using the online tools pkCSM and SwissADME, along with Discovery Studio software, further supporting its safety and bioavailability as an antimycobacterial agent.

Keywords: Mycobacterium tuberculosis, phytocompounds, mondoro myristica, ADMET.

Title: Insilico studies of therapeutic agents in Phytocompounds obtained from mondoro myristica (African nutmeg) against Mycobacterium tuberculosis

Author: Dearsly, Emmanuel Markus; Eze, Kingsley Chijioke; Oshatuyi, Olukayode; Shaibu, Aisha Oiza; Nwosu, Uzoamaka Amararachi; Mmadu, Michael Ezenwa

International Journal of Novel Research in Life Sciences                                                   

ISSN 2394-966X

Vol. 12, Issue 2, March 2025 - April 2025

Page No: 23-39

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 17-March-2025

Abstract: Sorghum (Sorghum bicolor) is a vital cereal crop, particularly for food security in arid and semi-arid regions. This study investigates the adoption determinants of improved sorghum varieties (Assosa-1 and Adukara) by smallholder farmers in the Metekel Zone, Benishangul-Gumuz Region, Northwestern Ethiopia. Employing a double-hurdle econometric model, the research analyzes primary and secondary data from 142 households sampled through multistage probability techniques. The findings reveal significant factors influencing both the decision to adopt and the extent of adoption, including access to credit, market access, proximity to cooperatives, sorghum yield, and total sorghum sold.

Male-headed households, closer distance to cooperatives, and access to financial and extension services were positively correlated with adoption levels. However, challenges such as limited access to improved seeds, financial constraints, and inadequate market infrastructure hinder broader adoption. The study underscores the importance of addressing these barriers through targeted policy interventions to enhance sorghum productivity and farmer livelihoods. The findings contribute to understanding technology adoption dynamics in humid lowland agroecologies, offering insights for agricultural development and food security strategies.

Keywords: Adoption, Improved Sorghum Variety, Metekel Zone, Double Hurdle Model.

Title: Determinants of Adopting of Improved Sorghum Variety (Assosa_1 & Adukara) Under Smallholder Farmers in Metekel Zone, Benishangul Gumuz Region, North Western Ethiopia

Author: Belete Woundefiraw, Welay Tesfay

International Journal of Novel Research in Life Sciences                                                   

ISSN 2394-966X

Vol. 12, Issue 2, March 2025 - April 2025

Page No: 9-22

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 10-March-2025

Abstract: Novel target compound, 2-(3-(5-cyano-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenoxy)acetic acid 2, was synthesized and evaluated for its anti-inflammatory activity using carrageenan-induced rat paw edema method in comparison with the selective COX-2 inhibitor, celecoxib. The results suggested that compound 2 proved good potency with edema inhibition rates of 22.28 and 25.23% at the third and fifth hours, respectively.  More SAR study and optimization are warranted for compound 2, which has the potential to be employed as oral anti-inflammatory drugs.

Keywords: Cyanopyridine; Anti-inflammatory; COX; Cyclooxygenase enzymes; Selective COX-2.

Title: Synthesis, and biological evaluation of novel 2-(3-(5-cyano-6-oxo-4-phenyl-1,6-dihydropyridin-2-yl)phenoxy)acetic acid as potential in vivo anti-inflammatory agent

Author: Alshimaa Kh. M. Ahmed, Mamdouh F. A. Mohamed, Eman A. M. Beshr

International Journal of Novel Research in Life Sciences                                                   

ISSN 2394-966X

Vol. 12, Issue 2, March 2025 - April 2025

Page No: 1-8

Novelty Journals

Website: www.noveltyjournals.com

Published Date: 05-March-2025