Vol 2 Issue 3 September 2015-December 2015
Umar Ibrahim Maryam, Nordin Simbak, Abdulkareem Umar, Ibrahim Haruna Sani, Atif Amin Baig, Thant Zin, Swethadri GKM
Abstract: Objective: The purpose of this study is to evaluate the anti-inflammatory and analgesic activities of aqueous extract of date palm fruit in rats.
Design and Setting: The study was an experimental research carried out at the medical laboratory of University Sultan Zainal Abidin, Kuala Terengganu, Malaysia.
Methods: Four groups of rats were conveniently assigned with six rats per group based on law of diminishing return. The groups received different interventions of 500mg of aqueous extract of date palm, 300mg of aqueous extract of date palm, Paracetamol and normal saline. Hot tail flick test was used to evaluate the analgesic activity of the rats, while 2.5% croton-oil was used to assess the anti-inflammatory activity in each group.
Results: Statistical significant median difference of the analgesic and anti-inflammatory effect of date fruit aqueous extract (DFAE) was revealed at (p= 0.001, χ2 =17.84) and (p= 0.002, χ2 =14.80) respectively. In addition, the significant difference of the analgesic effect of DFAE lies between normal saline and 500mg DFAE (p=0.001, χ2=-15.250). Likewise the significant difference of the anti-inflammatory effect of DFAE lies between group that received paracetamol and 300mg DFAE (p=0.027, χ2=0.027), paracetamol and normal saline (p=0.001, χ2=15.717), and 500mg DFAE and normal saline (p=0.031, χ2=11.467).
Keywords: Date Palm fruit, inflammation and pain.
Title: Anti-Inflammatory and Analgesic Activities of Aqueous Extract Date Palm(Phoenix Dactylifera L) Fruit in Rats
Author: Umar Ibrahim Maryam, Nordin Simbak, Abdulkareem Umar, Ibrahim Haruna Sani, Atif Amin Baig, Thant Zin, Swethadri GKM
ISSN 2394-7330
International Journal of Novel Research in Healthcare and Nursing
Novelty Journals