Vol 11 Issue 2 May 2024-August 2024
Promise Onyeka Ubanatu, Callistus Obinna Elegbua, Adeniyi Joshua Adedayo, Okafor John Egede, Bolaji Abdulazeez Akanni, Angela Adaku Elegbua
Abstract: Background: Suboptimal management of pain specially after surgery is dehumanizing and against human right. Incorporation of intravenous ascorbic acid into multimodal regimen has yielded encouraging results in prolonging time to first request for rescue analgesia and reduction in the demand for rescue analgesia.
Objective: To determine the effect of intravenous ascorbic acid as an adjuvant to suppository diclofenac and intravenous paracetamol on the time to first analgesia request and demand for rescue analgesia in Alex Ekwueme Federal University Teaching Hospital, Abakaliki.
Study Design: A randomized double blind controlled study involving parturients who received intravenous ascorbic acid as an adjuvant to suppository diclofenac and intravenous paracetamol for post-operative pain management after caesarean section and those who received intravenous sterile water (placebo), suppository diclofenac and intravenous paracetamol for post-operative pain management after caesarean section.
Methodology: A total of 164 parturients who satisfied the inclusion criteria were recruited for the study by systematic sampling. These were equal number of 82 participants in each group. Group A received intravenous ascorbic acid as an adjuvant to suppository diclofenac and intravenous paracetamol for post-operative pain management while Group B received intravenous sterile water (placebo), suppository diclofenac and intravenous paracetamol. The results were analysed using SPSS version 26 with appropriate tables and figures generated.
Results: The mean pain score at 2 hours after surgery was significantly higher in Group B when compared with Group A (6.9 ±1.4 vs.3.2 ±1.5; P<0.0001). At first request for analgesia, the mean NRS was significantly higher in Group B compared to Group A (6.9 ±0.9 vs.6.1 ±0.7; P<0.0001).Time to first request for analgesia was longer for parturients in Group A (180.6 ± 65.6 mins) than those in group B (92.4± 35.4 mins; P<0.0001). Group B participants 48 (58.5%) requested for rescue analgesia twice against 25 (30.5%) in Group A(P=0.007).
Conclusion: Intravenous ascorbic acid as an adjuvant to rectal diclofenac and intravenous paracetamol prolongs time to first request for rescue analgesia and also reduces the demand for rescue analgesia.
Recommendation: The use of post-operative multimodal analgesic regimen containing intravenous Vitamin C as adjuvant may be a useful strategy for improving analgesia.
Keywords: Ascorbic acid, Adjuvant, Analgesics, Analgesia, Rescue analgesia, Intravenous.
Title: EFFECT OF INTRAVENOUS ASCORBIC ACID AS AN ADJUVANT TO ANALGESICS ON TIME TO FIRST ANALGESIA REQUEST AND DEMAND FOR RESCUE ANALGESIA IN ABAKALIKI, SOUTH-EAST NIGERIA
Author: Promise Onyeka Ubanatu, Callistus Obinna Elegbua, Adeniyi Joshua Adedayo, Okafor John Egede, Bolaji Abdulazeez Akanni, Angela Adaku Elegbua
International Journal of Novel Research in Healthcare and Nursing
ISSN 2394-7330
Vol. 11, Issue 2, May 2024 - August 2024
Page No: 188-199
Novelty Journals
Website: www.noveltyjournals.com
Published Date: 30-July-2024